RYR2 and Duchenne muscular dystrophy: DMD is also characterized by an important Ca2+ homeostasis dysregulation with an excessive Ca2+ influx through activation of plasma membrane channels, such as TRP channels, associated with a high RyR activity (Wang et al, 2005; Williams & Allen, 2007; Bellinger et al, 2009; Fauconnier et al, 2010; Allen et al, 2016; Espinosa et al, 2016), importantly also linked to inflammation (Bellinger et al, 2009; Tidball & Villalta, 2009; Altamirano et al, 2012).