Importantly, RyR dysregulation has been shown to promote cardiomyopathy and skeletal muscle degeneration in the mdx mouse, and for instance, various strategies aiming to reduce the Ca2+ leaks from RyRs showed a significant improvement in its phenotype (Bellinger et al, 2009; Fauconnier et al, 2010; Sarma et al, 2010; Ather et al, 2013). The gene discussed is RYR2; the disease is cardiomyopathy.