While it is clear that the phosphorylation of PLN by PKA can release its inhibition of SERCA, several models have been proposed to show that the DCM mutations in PLN might change this regulation in either a phosphorylation-dependent or -independent manner (Ceholski et al., 2012a; Kim et al., 2015; Traaseth et al., 2009; Li et al., 2003; Nelson et al., 2018; De Simone et al., 2013). Here, PLN is linked to familial dilated cardiomyopathy.