25–35% of DCM cases have familial origin (Kureel et al., 2013), caused by inherited mutations in genes encoding proteins involved in muscle contraction and calcium handling, including phospholamban (PLN) (Alves et al., 2010; MacLennan, 2000; MacLennan and Kranias, 2003; Kranias and Bers, 2007). Here, PLN is linked to familial dilated cardiomyopathy.