PLAT and central nervous system cancer: Numerous studies have utilized gene expression datasets from TCGA, CGGA etc., to identify potential prognostic biomarkers in glioma such as GINS4 [56], SOCS3 [57], PTPRN [58], PLAT, IGFBP2, BCAT1, SERPINH1 [59], MAGEH1 [55] etc. Some of these markers have also been validated further in the patient cohort and also by functional analysis [56,57].