Further, among LGG, which includes grades II and III, similar association of higher PTMA expression was observed among IDH wildtype (HR = 1.61, 95% CI = 1.06–2.44, P=0.023, Figure 4D) and IDH mutant glioma (HR = 1.47, 95% CI = 1.09–1.98, P=0.011, Figure 4E), respectively. Here, IDH1 is linked to central nervous system cancer.