HMGB1 and brain ischemia: For example, sevoflurane suppresses the proliferation and invasion of neuroblastoma cells and induces apoptosis through miR-144-3p/YAP1 axis [34], and dexmedetomidine targets High-mobility group box 1 (HMGB1) protein through regulation of miR-205-5p, depressing cerebral ischemia/reperfusion inflammation and oxidative stress [35].