To investigate the exhaustion status of T‐cells in TP53‐mutated AML, we performed GSEA using three different exhaustion signatures, i.e., a signature of exhausted CD8+ T‐cells during chronic infection (CD8+ T‐cells in progressive HIV patients) and signatures of exhausted CD8+ T‐cells infiltrating liver and melanoma tumors, respectively.17, 18, 19. Here, CD8A is linked to acute myeloid leukemia.