Compared to their respective subpopulations from healthy controls, AML‐CTLs and AML‐Th cells displayed a significant enrichment of genes associated with exhausted CD8+ T‐cells during chronic infection; however, significant enrichment was not observed for signatures based on exhausted CD8+ T‐cells from solid tumors (Table 3; Figure 4). Here, CD8A is linked to acute myeloid leukemia.