In a study performing transcriptional profiling of different molecular subtypes of AML‐CTLs, upregulation of inhibitory molecules (CD244, CD160, LILRB1, CD300A, LAG3, TIGIT, PVRIG) and downregulation of stimulatory molecules (CD40LG, CD28, ICOS, TNFSF8, TMIGD2, TNFRSF25) were identified as compared to CTLs from healthy controls.4 The gene discussed is CD300A; the disease is acute myeloid leukemia.