We identified a slight overlap between our DEGs and other signature genes, which included a set of 14 genes increased expression in both clusters 2&6 and the ‘PMID33619369 Resistance signature 1’, indicating that both oxidative phosphorylation (i.e. COX8A, COX6A1, NDUFB2, COX7B and NDUFS6) and glycolysis/gluconeogenesis (i.e. ENO1, TPI1 and LDHA) play roles in MM relapse. Here, ENO1 is linked to Miyoshi myopathy.