FZD1 and Alzheimer disease: In addition, Sirt2 recruitment to Fzd1 and Fzd7 promoters depends on FoxO1 activity, leading to increased Sirt2 levels at these promoters and a concomitant H4K16ac deacetylation resulting in the repression of Fzd1 and Fzd7 genes in AD (Fig. 5).