We found increased FoxO1 levels at Fzd1 and Fzd7 promoters in NLGF hippocampal samples (Figs. 4B, S4H), suggesting that FoxO1 could contribute to the recruitment of Sirt2 to Fzd1 and Fzd7 promoters in the context of AD. Here, FZD7 is linked to Alzheimer disease.