Kaplan–Meier analysis indicated that high expression of all 21 genes (CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, GSDMA, GSDMB, GSDMC, GSDMD, IL18, IL1B, IL6, NLRC4, NLRP3, NOD1, NOD2, PLCG1, PRKACA, PYCARD, SCAF11) was associated with poor OS in low-grade glioma. Here, NLRP3 is linked to central nervous system cancer.