Kaplan–Meier analysis indicated that high expression of all 21 genes (CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, GSDMA, GSDMB, GSDMC, GSDMD, IL18, IL1B, IL6, NLRC4, NLRP3, NOD1, NOD2, PLCG1, PRKACA, PYCARD, SCAF11) was associated with poor OS in low-grade glioma. This evidence concerns the gene CASP1 and central nervous system cancer.