O-GlcNAcylation has been shown to promote cervical cancer cell proliferation, tumorigenesis and metastasis through various mechanisms, including increased cMyc stability5, NFκB-mediated CXCR4 (C-X-C Motif Chemokine Receptor 4) expression6,7, LXR (Liver X Receptor)-induced clusterin expression9 as well as HCF-1 (Host Cell Factor-1) and MLL (Mixed Lineage Leukemia) 5-mediated increase in E6/E7 expression3,4. The gene discussed is CXCR4; the disease is cervical cancer.