The SNPs that had nominally significant association to our primary and secondary outcomes—any IA, mIAA-first, GADA-first or T1D—were mainly from genes coding for proteins involved in double DNA strand repair and maintenance of telomeres (MRE11 and RAD50)42, DNA replication and repair (BLM)43, genome stability (ATM)44 or degradative endocytic trafficking (PIK3C3)45. This evidence concerns the gene PIK3C3 and type 1 diabetes mellitus.