In the CNS, Matsumoto et al.42 described the presence of CD200 + macrophages in the ischemic regions of a rat stroke model; however, CD200tr was expressed at higher levels in the ischemic core and CD200full in the contralateral and peri-ischemic regions, suggesting that macrophages in the lesion core escape the suppression induced by CD200-CD200R1 interactions. The gene discussed is CD200; the disease is Stroke.