MAPK1 and neoplasm: The study further demonstrated that ectopic expression of MAPK pathway mutations (mouse HRAS p.G12V, mouse MAPK1 p.D319N and p.E320K), but not respective WT-counterparts, could directly shape the HNSCC immune tumor microenvironment by attracting CD8+T cell infiltration in immunocompetent mouse allografts7.