Recent bioinformatic analysis of HNSCC patient tumors showed that MAPK-mutant HNSCC tumors, irrespective of HPV status, also have elevated CD8+T cell and dendritic cell infiltrations, together with immune-active cytolytic and interferon-gamma signatures in situ, suggestive of an active cytolytic CD8+T-inflamed status in these tumors. The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.