NRAS and melanoma: SOX10 immunofluorescence analysis in A375 (BRAF V600E), MeWo (wild-type for BRAF and NRAS), and 1205Lu (BRAF V600E) melanoma cell lines showed a similar level of heterogeneity and confirmed the co-presence of SOX10-low and -high expressing cells in basal culture conditions (Fig. 1e-g).