TNF and neoplasm: In SOX10 knockout cells, we observed an enrichment in pathways associated with the tumor microenvironment (epithelial-mesenchymal transition, TGFβ signaling, extracellular structure organization, apical junction, hypoxia, and angiogenesis) and metabolism (glycolysis pathway), as well as enrichment of the p53 pathway and TNFA signaling via NFκB (Fig. 2b, c and Supplementary Fig. 1A, B).