SREK1 and hepatocellular carcinoma: The nuclear-cytosol extraction further found that knockdown of SRSF10 could deplete the nuclear SREK1L and increase the SREK1S accumulated in the cytoplasm of HCCLM3 cells (Supplementary Fig. 5f), confirming that SRSF10 can promote nuclear SREK1L by maintaining exon 10 inclusion of SREK1 in HCC cells.