We found that SREK1L knockdown failed to inhibit the cell proliferation when UPF1 was depleted (Supplementary Fig. 3l), confirming the NMD regulation is important for SREK1L function in HCC cells.These data confirmed that B-T acts as a functional effector of SREK1L to promote HCC. This evidence concerns the gene UPF1 and hepatocellular carcinoma.