Moreover, the SRSF10 expression was also significantly correlated with SREK1 expression in TCGA-LIHC database (Supplementary Fig. 5j), and in six pairs HCC tissue samples we found that the long and short SREK1 proteins were significantly alternative spliced in T and MN tissue by evaluating the protein expression (Supplementary Fig. 5k), confirming that the upregulation of SRSF10 indeed promotes SREK1L expression in HCC. The gene discussed is SREK1; the disease is hepatocellular carcinoma.