SREK1 and hepatocellular carcinoma: To investigate the potential intrinsic regulatory mechanism(s) of SRSF10 in SREK1 splicing in HCC cells, the stable isotope labeling with amino acids in cell culture (SILAC) proteomic strategy was employed to reveal endogenous factors that interact with SRSF10 by IP using two commercial SRSF10 antibodies and mass spectrometry (Fig. 7a).