Firstly, we showed that the anti-tumour function of existing endogenous intrahepatic and intratumoural Vγ9Vδ2 TRM could be enhanced in an IPP-dependent manner by pre-treating HCC cell lines with the aminobisphosphonate ZOL, as previously shown for circulating Vγ9Vδ2 T-cells51. Here, IPP is linked to hepatocellular carcinoma.