After removal of ZOL, hepatoma cell lines were again co-cultured with IHL and were then able to trigger a significant increase in Vγ9Vδ2 T-cell effector function (IFN-γ, TNF-α, IL-2 expression, Fig. 6c, Supplementary Fig. 6a). The gene discussed is IFNG; the disease is hepatocellular carcinoma.