Using the GEPIA2 web server to interrogate the Cancer Genome Atlas database48, a combined CD69+CD103+ and γδ-TCR gene signature showed a favourable prognostic association with overall survival in HCC, not detected with an equivalent CD69+CD103+ αβCD8+ TCR gene signature (Supplementary Fig. 5e), although the TRM gene signature in the analysis may have been contributed to by other cell types preventing definitive conclusions. This evidence concerns the gene CD69 and hepatocellular carcinoma.