ITGAE and hepatocellular carcinoma: Using the GEPIA2 web server to interrogate the Cancer Genome Atlas database48, a combined CD69+CD103+ and γδ-TCR gene signature showed a favourable prognostic association with overall survival in HCC, not detected with an equivalent CD69+CD103+ αβCD8+ TCR gene signature (Supplementary Fig. 5e), although the TRM gene signature in the analysis may have been contributed to by other cell types preventing definitive conclusions.