Consistent with this, analysis of the Cancer Genome Atlas database using the Gene Expression Profiling Interactive Analysis 2 (GEPIA2) web server48, demonstrated a γδ-TCR gene signature (TRDC, TRGC1, TRGC2) to be significantly associated with overall survival in a larger cohort of HCC patients (n = 364), with higher Vγ9Vδ2 and non-Vγ9Vδ2 γδ-TCR gene expression signatures both associated with increased patient survival (Supplementary Fig. 4f, g)48,49. This evidence concerns the gene TRGC2 and hepatocellular carcinoma.