Overall, Vδ1 T-cells appeared higher in frequency and tended to be more activated with higher cytotoxic potential within HCC, while Vγ9Vδ2 T-cells, despite being selectively reduced in frequency in HCC, maintained high capacity for IFN-γ production and an equivalent ability to acquire an intratumoural CD69+CD49a+ or CD69+CD103+ TRM phenotype. The gene discussed is CD69; the disease is hepatocellular carcinoma.