IFNG and hepatocellular carcinoma: Importantly, CD69+CD49a+ Vγ9Vδ2 TRM isolated from the human liver displayed a greater increase in effector function (IFN-γ, IL-2 expression) compared to their non-resident (CD69−CD49a−) Vγ9Vδ2 T-cell counterparts when co-cultured with ZOL-treated hepatoma cell lines (Fig. 6e).