IPP and neoplasm: Therefore, based on previous studies51–53, we pre-treated HepG2 and HuH7 cells for 16–18 h with the aminobisphosphonate ZOL, which inhibits the enzyme farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway, promoting upstream accumulation of IPP within the tumour cell to trigger Vγ9Vδ2 TCR activation54.