ITGAE and hepatocellular carcinoma: Exposure to other prototypic hepatic cytokines, in particular combined IL-15 and TGF-β, also induced de novo expression of CD49a, and to a much lower extent CD103, on Vγ9Vδ2 T-cells, and therefore may be additional factors driving the induction of γδ TRM within the liver and HCC (Supplementary Fig. 7g).