The higher peak antibody levels and the lower rate of SARS-CoV-2 breakthrough infections suggest that the BNT162b2 rather than the ChAdOx1 nCoV-19 vaccine should be used for primary vaccination in infliximab-treated patients and, although untested, supports the use of BNT162b2 for third doses in all patients treated with an anti-TNF regardless of the primary vaccine type. The gene discussed is TNF; the disease is infection.