Not only is this the first study investigating sex differences in anxiety- and depression-like behavior in the oral CORT model and in BDNF Val66Met mice, but the novelty also arises from the investigation of genomic signatures that depended on the hippocampal region analyzed, with the dHPC and vHPC expressing distinct pattern of gene networks, particularly GRBGs and epigenetic modifiers. The gene discussed is BDNF; the disease is depressive symptom measurement.