These results, which are consistent with studies demonstrating the accumulation of ApoE and Lrp1 at nerve terminals (Bilousova et al., 2019), implicate the SV cycle in ApoE-mediated transport processes and suggest previously unappreciated roles for the SV cycle in the pathophysiology of neuroinflammation (Guttenplan et al., 2021) and age-related neurodegeneration (Bilousova et al., 2019). Here, APOE is linked to age.