MAPT and neurodegenerative disease: In addition, increasing evidences support that downregulation of DHCR24 could lead to Aβ production, apoptosis of neuronal or glial cells, hyperphosphorylation of microtubule-associated protein tau (tau), inhibition of autopagy, and inflammation, which are tightly associated with AD and other degenerative diseases [9, 24, 45, 71, 83, 95, 127, 155].