Furthermore, in a mouse model of desmosterolosis, DHCR24-KO mice brains showed complex changes in expression of lipid and sterol transcripts and synaptic plasticity transcripts, and the decrease of membrane cholesterol and disruption of membrane lipid raft and increased arborization synapse [3, 24, 71, 122]. The gene discussed is DHCR24; the disease is desmosterolosis.