MAPT and Alzheimer disease: Additionally, microglia responses have been associated with misfolded protein pathologies in cell cultures and monogenic rodent models [36, 48, 51, 67, 77, 83, 95] but AD and DLB samples often show overlapping pathologies, extracellular senile plaques made of amyloid-β (Aβ) peptides, intracellular neurofibrillary tangles (NFTs) built from hyperphosphorylated tau (pTau) and intracellular aggregation of phosphorylated α-synuclein (pSyn) such as Lewy bodies [47], with different gradients of severity [12, 59, 60, 88].