A very recent study showed that ALKBH5 deficiency decreased the mRNA stability and protein secretion of IFN-γ and C-X-C motif chemokine ligand 2 (CXCL2) in CD4+ T cells, thereby alleviating experimental autoimmune encephalomyelitis (Fig. 2D) [56]. The gene discussed is CXCL2; the disease is experimental autoimmune encephalomyelitis.