SLC5A2 and hydrops fetalis: The cardiorenal effects of both GLP-1RA and SGLT-2 inhibitors can be summarized as follows: GLP-1RA have moderate benefits on MACE (major cardiovascular events), may reduce all-cause mortality and hospitalization for HF (HHF), and have a robust effect in reducing the incidence of macroalbuminuria [12]; SGLT-2 inhibitors cause robust reduction of HHF and the renal outcome, and moderate reduction of CV or total deaths and MACE [13].