As for nonfatal stroke, Fig. 2 and Additional file 1: Fig. S5 show that GLP-1RA were associated with lower risks as compared with placebo (16% lower risk), DPP-4 inhibitors (15% lower risk) and SGLT-2 inhibitors (10% lower risk), but the difference was statistically significant as compared with placebo only. This evidence concerns the gene SLC5A2 and Stroke.