In addition, results from co-incubation of human GC cells with anti-CD3/CD28 beads-activated T cells showed that BGC-823 and MGC-803 cells alone grew stably in vitro, whether LSD1 was knocked out or not (Fig. 1e), while these two cancer cell lines could be killed by activated T cells more easily when LSD1 was absent (Fig. 1f). This evidence concerns the gene CD28 and cancer.