Consistent with higher inherent sensitivity to fluvastatin, preneoplastic MCF10.AT1 cells had significantly lower expression of 12 out of 17 cholesterol biosynthesis pathway genes that ranged from 76% lesser expression for TM7SF2 to 15% lower expression for FDFT1 relative to MCF10.DCIS cells (p ≤ 0.05, Fig. 1a and supplementary Fig. 1). The gene discussed is TM7SF2; the disease is ductal breast carcinoma in situ.