The autoimmune markers panel included Anti-nuclear autoantibodies (ANA), Anti-SSA/Ro, Anti-La/SSB, Anti-Jo1, Anti-RNP; Anti-topoisomerase I (Anti-SCL 70); Central-antineutrophil cytoplasmatic antibody (c-ANCA); Perinuclear-antineutrophil cytoplasmatic antibody (p-ANCA); Rheumatoid factor; Anti-cyclin citrullinated peptide (Anti-CCP); Lupus Anticoagulant; Anti-cardiolipin; Anti-beta2 glycoprotein; Anti-endomysium and Anti-tissue transglutaminase autoantibodies. This evidence concerns the gene SSB and systemic lupus erythematosus.