In another study, the IGF-1R/insulin receptor TKIs PQIP exhibited increased antitumor effects when administered in combination with chemotherapeutic drugs (including oxaliplatin, irinotecan, and 5-fluorocrail) against CRC xenografts derived from HT-29, LS513, and HCT116 cell lines [84]. This evidence concerns the gene IGF1R and colorectal carcinoma.