IGF1R and colorectal carcinoma: Moreover, in a randomized placebo-controlled clinical study, few patients with advanced CRC who were refractory to first-line chemotherapy gained survival benefits from combination of monoclonal anti-IGF1R antibody AMG 479 (ganitumab) and FOLFIRI (tetrahydrofolic acid, irinotecan, and 5-fluorouracil) chemotherapy in terms of median progression free survival [88].