STAT1 and hyper-IgE syndrome: Other IEI were represented by only one patient, including late-onset combined immunodeficiency (LOCID), hyper IgE syndrome (HIES), Kabuki syndrome (KS), STAT-1 gain-of function chronic mucocutaneous candidosis (CMC), Wiskott-Aldrich syndrome (WAS), X-linked agammaglobulinemia (XLA), X-linked lymphoproliferative syndrome type 1 and type 2 (XLP-1, 2), and X-linked hyper IgM syndrome (Figure 2).