Overexpression of EGFR has been associated with poor response outcomes to ICI in various cancer models, including non-small cell lung cancer and neuroblastoma (105, 106)Also, the EGFR family member, HER2, was shown to be inversely correlated with MHC-I expression in breast cancer and impairs T cell recognition of peptide: MHC-I complexes (107, 108). The gene discussed is EGFR; the disease is cancer.