GZMB and B-cell chronic lymphocytic leukemia: Interestingly, the Tregs A subpopulation is positive for already reported markers of CLL-related Tregs, including IL-10, LAG-3, granzyme B, EOMES, as well as share a unique gene expression signature of chemokines that may support leukemia progression and formation of leukemic microenvironment (35, 36).