Although Tregs A exhibited comparable transcription changes as compared to Effector Tregs (up-regulation of Il10 and Havcr2/Tim3 and down-regulation of Sell and Ccr7), we identified important differences suggesting a particular gene modulation in this specific Tregs population found in CLL (e.g. Eomes, Prf1, Itgae, Cxcl10) (Supplementary Figure 4D). The gene discussed is PRF1; the disease is B-cell chronic lymphocytic leukemia.