CXCR3 and cancer: CXCL10 is a selective ligand for CXCR3, and the CXCL10/CXCR3 signaling pathway regulates leukocyte trafficking and angiogenesis through paracrine interactions, while signaling of autocrine CXCL10/CXCR3 in tumor cells can promote growth of cancer and metastasis by regulating cell adhesion, invasion, and migration capabilities (34, 35).