The treatment strategy for patients with <i>EGFR-</i>mutated non-small cell lung cancer who are refractory to EGFR TKIs has become a current dilemma and challenge.<h4>Case presentation</h4>A case of a 69-year-old male patient suffering from intermittent cough and hemoptysis was diagnosed with <i>EGFR</i>-mutated advanced SqCLC (stage cT2bN2M1). This evidence concerns the gene EGFR and non-small cell lung carcinoma.