The results showed that FBXW7, CREBBP, RELN, PTEN, TP53, EP300, PRDM1, and JAK1 mutations were related to the prognosis (5-year OS, EFS, or RFS) of children with T-ALL (P values less than 0.05, Supplementary Table 12). Here, TP53 is linked to acute lymphoblastic leukemia.