MARK1 and acute lymphoblastic leukemia: In order to further explore the value of gene mutations in the prognosis of T-ALL, we divided the 88 mutant genes detected with NGS into 10 groups: 1) NOTCH signaling pathway, 2) Ras/Protein phosphatase/MARK/PI3K signaling pathway, 3) Transcription factor/regulation, 4) Epigenetic modulators, 5) Jak-Stat Signaling Pathway, 6) Splicing and mRNA processing regulation, 7) NF-KB pathway, 8) Wnt/β-Catenin pathway, 9) Receptor/Nonreceptor tyrosine kinase signaling pathway, and 10) Cyclins and Cell Cycle Regulation (19, 24–26).