Consistent with this notion, it has been shown that patients with wild type SF3B1 and mutant DNMT3A mutations had an inferior overall survival and higher risk of AML transformation than ones with mutant SF3B1 and mutant DNMT3A (40), and DNMT3A mutations predicted worse prognosis in the SF3B1-wild type patients but not SF3B1-mutated patients (31). The gene discussed is DNMT3A; the disease is acute myeloid leukemia.