NPM1 and acute myeloid leukemia: Mutations of NPM1 (odds ratio 2.3, range: 1.8-2.3) and PTPN11 (odds ratio 2.1, range: 1.3-3.3) were enriched in DNMT3A R882 mutant AMLs (Figure 2A), while TP53 (odds ratio 0.3, range: 0.2-0.6) and U2AF1 (odds ratio 0.4, range: 0.2-0.7) were more frequently co-mutated in non-R882 mutant AML cases (Figure 2B).