After dividing the patients into mutation (n=46) and wild (n=322) groups, we found that more than half of the patients in the mutation group harbored RB1 mutation (65.2%, the common variants in lung cancer were C706F, G748K, and R661W), followed by CDKN2A (28.3%, the common variants in LUAD were R80Q and H83Y), CCNE1 (10.9%), CDK4 (4.3%, the common variants in LUAD were R24L and R24C) and CCND1 (2.2%). This evidence concerns the gene CDKN2A and lung cancer.