A major factor leading to this phenomenon is the ability of the tumors to compromise the immune response in the tumor microenvironment (TME) and gain resistance to immune checkpoint inhibitors (46), mainly through insufficient T-cell infiltration of the tumor, T-cell exhaustion, and also the lack of response to IFN-γ (44, 47), which are important anticancer mechanisms used by the immune system. This evidence concerns the gene IFNG and neoplasm.