A total of 52 patients had hypopituitarism, including 23 cases of central hypothyroidism, 10 of hypogonadotropic hypogonadism, 5 of hypoadrenalism, 21 of growth hormone deficiency (14 partial deficiency and 7 complete deficiency), and 8 of increased ACTH level. This evidence concerns the gene POMC and Central hypothyroidism.