Other reasons for these results should be considered, because patients who underwent surgery received a pathological diagnosis, while in other symptomatic patients who received conservative treatment, the presence of a RCC and ACTH secreting pituitary microadenoma (13) or even a pituitary adenoma and concomitant RCC (14–16) could not be definitely excluded. The gene discussed is POMC; the disease is pituitary gland adenoma.