A more recent study, reported a germline CHEK2 pathogenic variant (c.596dupA, p.Tyr199Ter) in the proband and in five additional members of a Portuguese Roma family with MNG and/or PTC; in this same family, two women were affected by breast cancer and classic PTC and one of the men by prostate cancer and PTC (38). This evidence concerns the gene CHEK2 and breast cancer.