POT1 and familial papillary or follicular thyroid carcinoma: Nevertheless POT1 germline mutations have been implicated in susceptibility for melanoma, displastic nevi and FNMTC in some families (13, 14); and more recently, a novel germline variant (p.Val29Leu) of POT1 gene was reported in one family affected solely by NS-FNMTC (16).