Interestingly, germline mutations in non-syndromic familial PTC impact multiple processes (proliferation, migration and/or cell survival, telomere dysfunction, tumor progression, autophagy, mitochondrial metabolism, chromosomal stability, angiogenesis, etc.), while somatic events are grouped mainly within the mitogen-activated protein kinase (MAPK) signaling pathway. The gene discussed is WNK2; the disease is neoplasm.