CHEK2 and Familial prostate cancer: A more recent study, reported a germline CHEK2 pathogenic variant (c.596dupA, p.Tyr199Ter) in the proband and in five additional members of a Portuguese Roma family with MNG and/or PTC; in this same family, two women were affected by breast cancer and classic PTC and one of the men by prostate cancer and PTC (38).