MAP2K5 and obesity due to melanocortin 4 receptor deficiency: For instance, Lv et al. reported that among the 19 SNPs previously identified from GWAS of obesity, only SEC16B rs543874, MC4R rs17782313, MAP2K5 rs2231323, and KCTD15 rs11084753 were significantly associated with the risk of obesity in school-aged children [15].