APOB and familial hyperaldosteronism: A mutation in the APOB gene causes familial defective apolipoprotein B-100 (FDB), an autosomal dominant disease of lipid metabolism similar to LDL receptor-mediated FH (non-FDB) characterised by elevated plasma LDL-C levels (Vega and Grundy, 1986; Innerarity et al., 1987).