HLA-C and infectious disease: It seems clear why should self/non-self discrimination via MHC/HLA antigen-presentation system of foreign (e.g., viral or bacterial) proteins on cell surface be involved in the defense against infectious diseases, but the association of particular MHC/HLA sequence variants—the self haplotypes—with a variety of non-infectious age-related diseases [reviewed in (Steele, 2014) and in this volume] is less obvious.