FMR1 and fragile X-associated tremor/ataxia syndrome: Importantly, the sole expression of expanded CGG repeats, embedded in the 5′UTR of FMR1, in cell or animal models is sufficient to cause neuronal cell dysfunctions and to induce formation of the typical FXTAS intranuclear inclusions (Jin et al., 2003; Willemsen et al., 2003; Arocena et al., 2005; Entezam et al., 2007; Hashem et al., 2009; Todd et al., 2013; Hukema et al., 2015).