Interestingly, a similar mechanism was recently identified in amyotrophic lateral sclerosis and frontotemporal dementia, where an expansion of G4C2 repeats located in the first intron of the C9ORF72 gene is translated into a polyglycine-alanine dipeptide repeat (polyGA DPR) protein through translation initiation at a CUG near-cognate start codon located 24 nucleotides upstream of the repeats (Green et al., 2017; Tabet et al., 2018; Sonobe et al., 2018; Almeida et al., 2019; Boivin et al., 2020; Sonobe et al., 2021; Figure 3). Here, C9orf72 is linked to amyotrophic lateral sclerosis.