C9orf72 and amyotrophic lateral sclerosis: Interestingly, expression of this polyG protein promotes alterations of the nucleocytoplasmic transport (Zhong et al., 2021), which is reminiscent of the pathogenicity described for FMRpolyG in FXTAS (Sellier et al., 2017), as well as for DPR proteins expressed from the G4C2 repeats in the C9ORF72 gene in ALS/FTD (Jovičić et al., 2015; Hayes et al., 2020).