NOTCH2NLC and neuronal intranuclear inclusion disease: First, a loss of function of the NOTCH2NLC (abbreviated N2C) protein is unlikely as the CGG repeats are located 140 nucleotides ahead of the ATG start site of this protein, and as NOTCH2NLC mRNA levels are found unaltered, or even increased, in blood, brain, fibroblasts and muscle samples of individuals with NIID or OPDM3 (Sone et al., 2019; Ishiura et al., 2019; Tian et al., 2019; Yu et al., 2021).