KDR and nonpapillary renal cell carcinoma: In this review, we discuss the recent and emerging first-line treatment options in ccRCC, with a focus on axitinib/pembrolizumab, axitinib/avelumab, cabozantinib/nivolumab, and lenvatinib/pembrolizumab and compare their efficacy to nivolumab/ipilimumab as well as VEGFR TKI and CPI monotherapy.