IL6 and neoplasm: The polysaccharides could activate macrophages, T-lymphocytes, B-lymphocytes, natural killer cells, and cytokines that are closely related to the killing of the tumor, such as tumor necrosis factor (TNF-α), interferon (IFN-γ), and interleukins (IL-2, IL-4, IL-6, and IL-12) (71).