TP53 and lung cancer: Jie et al. also discovered that Auricularia polytricha polysaccharides (APPs)-mediated cell cycle arrest at G0/G1 phase, mainly through inhibition of CDK/cyclin complexes formation, downregulating cyclin A, cyclin D, and CDK2, and activating p21 in a p53-dependent (p53 is an effective tumor suppressor) event in a human lung cancer cell line, which is the A549 (56).