Amplification of the Sonic Hedgehog pathway is observed in the best characterized medulloblastoma subgroup (SHH), with 30% of human tumors having mutations in Patched, Sufu (Suppressor of Fused Homolog), Smoothened, or other genes in this pathway (Northcott et al., 2011, 2017). Here, SUFU is linked to medulloblastoma.