High-risk genes in the model, including ANGPTL4, LDHA, and NPAS2, have been reported to promote angiogenesis, glycolysis, drug tolerance, the invasive and migratory potential, and cell cycle and apoptosis in lung cancer patients or cell lines (Galaup et al., 2006; Park et al., 2016; Gu et al., 2017; Li et al., 2018). The gene discussed is NPAS2; the disease is lung cancer.