Both these proteins serve in CLL cells as substrates of Lyn (Ten Hacken et al., 2013; Martini et al., 2017) and at the same time were found to dynamically interact with ROR1 and control the ROR1-induced migration (Hasan et al., 2017; Hasan et al., 2019). This evidence concerns the gene LYN and B-cell chronic lymphocytic leukemia.