Ephrin-A5−/− mice in a mixed genetic (129/Sv:C57BL/6) background have severe and nearly whole cataracts at 6 months of age with posterior capsule rupture, and lenses from younger mice have many cellular abnormalities, including vacuoles and alterations in the fiber cell shape, size, organization, and packing (Cooper et al., 2008; Son et al., 2013; Biswas et al., 2016; Zhou and Shiels, 2018). This evidence concerns the gene EFNA5 and cataract.