EPHA1 and Age-related cataract: Recently, disruption of Eph-ephrin signaling in human patients has been associated with congenital and age-related cataracts, defined as any opacity in the transparent eye lens (Shiels et al., 2008; Jun et al., 2009; Zhang et al., 2009; Kaul et al., 2010; Tan et al., 2011; Sundaresan et al., 2012; Dave et al., 2013; Patel et al., 2017; Berry et al., 2018; Zhai et al., 2019).