In addition, transfection experiments using epithelial cell culture systems, such as Madin-Darby canine kidney (MDCK) and human colorectal adenocarcinoma (Caco-2) epithelial cells, revealed that SAM domain mutations of EphA2, namely p.T940I and p.D942fsXC7, affect the intercellular contacts due to destabilization of mutant EphA2 proteins (Dave et al., 2016). Here, EPHA2 is linked to colorectal adenocarcinoma.