Recent studies have confirmed that various markers of the systemic inflammatory response, for example, the C-reactive Protein (CRP), Platelet to Lymphocyte Ratio (PLR), Lymphocyte to Monocyte Ratio (LMR), and Neutrophil to Lymphocyte Ratio (NLR), all correlate to the prognosis of a myriad of tumors such as high-grade glioma (He et al., 2021b), colorectal cancer (Dagmura et al., 2021), head and neck cancer (Saroul et al., 2021), oral squamous cell cancer (Yamagata et al., 2021), and gastric cancer (Liu et al., 2021). This evidence concerns the gene CRP and head and neck cancer.