HMGB1 and cancer: Studies have revealed that high mobility group box-1 (HMGB-1) in virus therapy with oncolytic adenoviruses as well as human inhibitory receptors Ig-like transcript 2 (ILT2) in the treatment of cancer with vaccinia virus can be used as predictive, prognostic, and treatment monitoring biomarkers (Zloza et al., 2014; Liikanen et al., 2015).