Diseases arising from folding-deficient variants of other solute carrier (SLC) 6 transporters are not without precedent: e.g., misfolded variants of the dopamine transporter (DAT, SLC6A3) and the creatine transporter 1 (CRT-1, SLC6A8) cause infantile/juvenile parkinsonism-dystonia and the creatine transporter deficiency syndrome, respectively (Farr et al., 2020; Bhat et al., 2021). This evidence concerns the gene SLC6A8 and Dystonia.